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Original Research Article


 

The effect of Garcinia kola extract on lipopolysaccha-ride-induced tissue damage in rats

 

Tebekeme Okoko*, Solomon Ndoni

Biochemistry Division, Department of Chemical Sciences, Niger Delta University, PMB 71, Wilberforce Island, Bayelsa State, Nigeria.

*Corresponding author: E-mail: tebebuddy@yahoo.com      

   

Received: 1 June 2008                                                                           Revised accepted: 6 October 2008

 

Tropical Journal of Pharmaceutical Research, February 2009; 8(1): 27-31

Abstract

 

Purpose: To study the effect of the crude methanol extract of Garcinia kola seed on lipopolysaccharide (LPS)-induced tissue damage in rats

Methods: A total of 16 rats were split equally into four treatment groups: Normal controls, LPS-treated only, LPS-treated + 100 mg/kg body weight (b.w.) extract, LPS-treated + 250 mg/kg b.w. extract. LPS was administered via the intraperitoneal route once and the extract orally administered to the rats for 14 days. Indices of liver and kidney function were later assessed.

Results: The results showed that LPS caused marked elevations in the blood levels of alanine aminotransaminase, aspartate aminotransaminase, creatinine, urea, nitric oxide and a significant reduction in the catalase activity in both liver and kidney. The thiobarbituric acid reactive species were also increased in liver. These levels were brought to near control values when the rats were fed with the extract. The changes were more pronounced in the rats given the 250 mg/kg b.w. of the extract.

Conclusion: The data suggest that Garcinia kola significantly reduced the tissue damage induced by LPS which may be dose-dependent. This is probably due to the interaction of the various phytochemicals with LPS and/or to the fact that the extract possesses significant antioxidant properties.

 

Keywords: Garcinia kola, lipopolysaccharide, creatine, urea, hepatotoxicity, nephrotoxicity

 

   

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