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Original
Research Article
Fast Dissolving
Tablets of Aloe Vera Gel
Jyotsana
Madan1, AK Sharma2, Ramnik Singh3
1UP
Technical University, Lucknow , India, 2MJP
Rohilkhand, University, Bareilly,India, 3Sri
Sai College of Pharmacy, Pathankot, India
*Corresponding
author:
Email:
jrmadan@hotmail.com,
Mobile: +919463230415, Residence:+911862247868
Received: 06 August
2008
Revised accepted: 17 September 2008
Tropical
Journal of Pharmaceutical Research, February
2009; 8(1):
63-70
Abstract
Purpose: The objective of this work was to
prepare and evaluate fast dissolving tablets of the
nutraceutical, freeze dried Aloe vera gel.
Methods: Fast dissolving tablets of the
nutraceutical, freeze-dried Aloe vera gel, were
prepared by dry granulation method. The tablets were
evaluated for crushing strength, disintegration time,
wetting time, friability, drug content and drug release.
A 32 full factorial design was applied to
investigate the combined effect of two formulation
variables - amounts of microcrystalline cellulose and
mannitol.
Results: The results of multiple regression
analysis revealed that in order to obtain a fast
dissolving tablet of the Aloe vera gel, an
optimum concentration of mannitol and a higher content
of microcrystalline cellulose should be used. A response
surface plot was also provided to graphically represent
the effect of the independent variables on the
disintegration time and wetting time. The validity of
the generated mathematical model was tested by preparing
a check point batch.
Conclusion: This investigation has demonstrated
that satisfactory fast dissolving Aloe vera gel
tablets can be formulated. It also showed the potential
of experimental design in understanding the effect of
formulation variables on the quality of fast dissolving
tablets.
Keywords: Aloe vera, Fast dissolving
tablet, Factorial design, Mathematical model, Mannitol,
Microcrystalline cellulose |
