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Research
Article
Galangoflavonoid
Isolated from Rhizome of Alpinia galanga (L) Sw (Zingiberaceae)
SB Jaju1*, NH Indurwade1, DM
Sakarkar1, NK Fuloria2, MD Ali3,
S Das4 and SP Basu4
1S.N.
Institute of Pharmacy, Pusad, Amravati University, M.S
-445 204, 2Ram-eesh Institute of Vocational
and Technical Education, Knowledge Park–II, Greater
Noida, UP 201 306, 3 Department of
Pharmacognosy, Jamia Hamdard, New Delhi, 110 062, 4
Department of Pharmaceutical Technology, NIET,
Knowledge park –II, Greater Noida, UP, 201 306, India
*Corresponding author:
E-mail:
shivani_jaju@rediffmail.com Tel: 09911225981
Received: 7 March 2009
Revised
accepted: 02 October 2009
Tropical
Journal of Pharmaceutical Research, December 2009; 8(6):
545-550
Abstract
Purpose:
The purpose of this
investigation was to isolate novel flavonoids from
Alpinia galanga rhizomes.
Methods:
The methanol extract of Alpinia galanga was
subjected to column chromatography and eluted with ethyl
acetate-methanol (9:1) to yield a compound,
galangoflavonoside (AG 11). The structure of the
compound was elucidated by various spectral techniques
(UV, IR, 1H NMR, 13C NMR, and MS).
Results:
Chemical investigation of the extract furnished a new
flavonoid galangoflavonoside (AG 11). Conclusion:
The isolated compound, galangoflavonoside (AG
11,) could be a potential therapeutic compound as well
as serve as a lead compound in the synthesis of other
useful flavonoids. Isolation of the galangoflavonoside
from Alpinia galanga rhizomes is being reported, to the
best of our knowledge, for the first time.
Keywords:
Alpinia galangal; Methanol extract; Galangoflavonoside;
Spectral techniques |
