The Effect of
Chemical and Physical Enhancers on Trolamine Salicylate
Permeation through Rat Skin
Behzad Sharif Makhmal Zadeh* and Mohammad Hossin
Hasani
School of Pharmacy, Jundishapour University of
Medical Sciences, Ahvaz, Iran
*For correspondence:
E-mail:
bsharifmakhmalzadeh@yahoo.com Tel:
+98-611-3373747; Fax: +98-611-3361544
Received: 13
February
2010 Revised
accepted: 22 October 2010
Tropical
Journal of Pharmaceutical Research, December 2010;
9(6):
541-548
Abstract
Purpose: To
achieve percutaneous delivery of trolamine salicylate to
muscle and joints for the treatment of inflammatory
muscle, tendon and joint diseases.
Methods:
Trolamine salicylate permeability parameters through rat
skin were evaluated with and without chemical enhancers
- Transcutol, eucalyptus oil, oleic acid and sodium
lauryl sulfate – using the permeability cell technique.
Results: The
main barrier for trolamine salicylate permeability was
the epidermis layer of the skin. Also, partitioning from
the aqueous donor phase into the skin was the
rate-limiting step for drug flux. Transcutol and
eucalyptus oil were the most effective enhancers as they
increased flux 11-fold. Sodium lauryl sulfate disrupted
the lipid structure of the skin and thus increased
diffusion coefficient 3-fold. Supersaturation technique
did not increase flux. Propylene glycol in cosolvent
system increased drug solubility in donor phase and
partitioning.
Conclusion:
Trolamine salicylate exhibited less flux and diffusion
coefficient through rat skin than salicylic acid due to
its hydrophilic property. Partitioning from vehicle into
skin was the rate-limiting step for trolamine salicylate
permeability through rat skin.
Keywords:
Trolamine salicylate, Percutaneous absorption, Chemical
enhancers, Supersaturation technique, Differential
scanning calorimetry.
