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Research Article

 

Immunomodulatory Activity of the Methanol Extract of Amorphophallus campanulatus (Araceae) Tuber

 

AS Tripathi1*, V Chitra1, NW Sheikh1, DS Mohale2 and AP Dewani2

1SRM College of Pharmacy, Kathankulathur 603 203, Chennai, 2P.W. College of Pharmacy, Yavatmal 445001, Maharashtra, India

 

*Corresponding author:  E-mail: shloksk@rediffmail.com  Tel: +91-7232237165, 9271279752

Received: 4 July 2009                                                                            Revised accepted: 27 August 2010

Tropical Journal of Pharmaceutical Research, October 2010; 9(5): 451-454

 

Abstract

 

Purpose: Traditionally, Amorphophallus campanulatus tuber is used for the treatment of enlarged spleen, rheumatism and tumour. Therefore, this study was designed to evaluate the immunomodulatory activity of the plant material.

Method: The effect of the methanol extract (ME) of Amorphophallus campanulatus tuber on immunological function in mice was studied using charcoal clearance, spleen index and delayed-type hypersensitivity (DTH) response models. The extract was administered orally at doses of 250 and 500 mg/kg.

Results: The extract exhibited immunomodulatory activity by causing a significant decrease in charcoal clearance, spleen index and delayed-type hypersensitivity (DTH) response.

Conclusion: Amorphophallus campanulatus caused decreases in the charcoal clearance rate and cellular immunity by facilitating the footpad thickness response to sheep red blood cell (RBC) in sensitized mice.

 

Keywords: Amorphophallus campanulatus; immunomodulatory activity, Charcoal clearance, Spleen index, Delayed-type hypersensitivity response.

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